Ultimate guide on how to sort out the imbalance of Omega-3 and Omega-6

Published by


1. Problem of imbalance of Omega-3 and omega-6

When patients visit their doctors with complaints potentially related to an imbalance of omega-3 and omega-6, their words often reflect deep concern and discomfort:

1. Jennifer, 34 years old: "Doctor, I constantly feel drained. Even after a full night's sleep, I feel like I haven't rested at all."
2. Mike, 42 years old: "Every morning, I wake up with joint pain. It started about a year ago, and I thought it was just aging, but now it's becoming unbearable."
3. Emily, 28 years old: "My skin has become so sensitive lately! Everything I wear seems to irritate it, and I'm constantly itching."
4. Brian, 37 years old: "Lately, I've noticed I'm becoming very forgetful. I often lose my train of thought and forget important stuff."
5. Sarah, 31 years old: "I wake up multiple times during the night, and in the morning, I feel completely shattered. What's wrong with me?"
6. Chris, 40 years old: "My mood swings are getting out of control. I often feel a deep sadness, even when everything in my life seems fine."

These patient narratives illustrate just how much an imbalance in omega-3 and omega-6 can affect the quality of their lives, emphasizing the importance of a balanced diet and paying attention to one’s health.

An improper ratio of omega-3 to omega-6 in the body can manifest itself through a variety of clinical symptoms. Patients often present to physicians with these complaints:

  • Chronic fatigue: A constant feeling of tiredness and lack of energy, unrelated to exercise or lack of sleep.
  • Joint pain: Constant or intermittent pain that increases with movement or upon awakening.
  • Skin sensitivity and rashes: Skin manifestations such as red spots, itching, flaking or eczema.
  • Concentration Disorders: Difficulty concentrating, forgetfulness, and decreased productivity.
  • Irregular sleep cycle: Problems falling asleep, frequent awakenings at night, or poor quality short sleep.
  • Lowered mood: Intermittent or persistent feelings of sadness, apathy or depression.

Thus, an imbalance of omega-3 and omega-6 can cause a host of health problems, many of which in their initial stages may be mistaken for symptoms of other diseases or stressful conditions. Therefore, it is important to pay close attention to your well-being and, at the first signs, contact a specialist for consultation.

2. Solution. Which diet will be most effective and adhere to the recommended omega-6 to omega-3 ratio

To maintain the recommended ratio of omega-6 to omega-3, it’s crucial to incorporate omega-3 rich foods into your diet and limit the consumption of high omega-6 products. Here are a few recommendations and diets that can assist:

  • Mediterranean Diet: This diet emphasizes the consumption of olive oil, fish, nuts, and seeds. It also includes plenty of vegetables, fruits, and whole grains.
  • Grass-fed Animal Diet: Animals raised on grass often have a more favorable omega-6 to omega-3 ratio in their meat compared to grain-fed animals.
  • Consumption of fatty fish: Fish, especially fatty varieties like salmon, herring, mackerel, and sardines, contain substantial amounts of omega-3.
  • Limit the intake of vegetable oils rich in omega-6: Such oils include soybean, sunflower, corn, and safflower oil. Opt for olive oil or walnut oil instead.
  • Incorporate nuts and seeds into your diet: Walnuts, flaxseeds, and chia seeds are rich in omega-3.
  • Limit the consumption of processed foods: Many processed items contain vegetable oils rich in omega-6 and other undesirable ingredients.
  • Read product labels: Check packaging labels to avoid products high in omega-6-rich oils.

For most individuals, the key is to consciously reduce omega-6 intake and boost omega-3 consumption. However, it’s always advisable to discuss any dietary changes with a doctor or nutrition specialist.

What is the safest and most effective way to get omega-3?

For most people, the safest and most effective way to get omega-3 fatty acids is to consume natural sources, especially oily fish, and supplement this diet with supplements. Here are recommendations for choosing omega-3 sources:

Fatty fish:

Fatty fish such as salmon, herring, sardines, mackerel and mackerel contain high amounts of EPA and DHA.
Consuming fish 1-2 times a week can help meet your omega-3 needs.
However, some fish may contain contaminants such as mercury. Prefer wild fish species and limit consumption of species high in mercury, such as swordfish, shark and king mackerel.

Plant Sources:

Flax seeds, walnuts, and chia seeds contain alpha-linolenic acid (ALA), a precursor to EPA and DHA.
Even though the conversion of ALA to EPA and DHA in the human body is inefficient, plant sources are still a beneficial addition to the diet, especially for vegetarians and vegans.

Omega-3 supplements:

For those who don’t consume enough fish or are looking for alternative sources, supplements can be a useful way to get omega-3.
Fish oil is a popular supplement, but for vegans or those who don’t want to consume animal products, seaweed-based supplements are available.
When choosing a supplement, make sure it has been tested to be free of contaminants and is manufactured by a reputable company.
Consult your doctor or nutritionist before starting supplements.


There is minimal risk of side effects when consuming omega-3 from natural sources.
However, some supplements may have side effects or drug interactions. You should always consult your doctor before starting supplements.

Avoid overeating the same omega-3 source and try to diversify your diet. This will help minimize the risk of consuming contaminants from a particular source and ensure you are getting all the omega-3 species you need.

What are ALA EPA and DHA?

ALA (alpha-linolenic acid), EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) are the three main types of omega-3 fatty acids.

  • ALA (alpha-linolenic acid): This is a plant-based omega-3 fatty acid.
    It is a precursor to EPA and DHA, although the conversion process in the human body is inefficient.
    Most common sources: flax seeds, walnuts, chia seeds, vegetable oils such as canola and soybean oil.
  • EPA (eicosapentaenoic acid): A polyunsaturated omega-3 fatty acid primarily found in marine fish and algae.
    Has anti-inflammatory properties and may help manage certain conditions such as depression and cardiovascular disease.
    Main sources: fatty fish such as salmon, herring, sardines, mackerel and tuna, as well as some seaweed-based supplements.
  • DHA (docosahexaenoic acid): Another polyunsaturated omega-3 fatty acid, mainly found in marine fish and algae. Particularly important for brain and eye development and function. Important for pregnant and nursing mothers as DHA supports the development of the baby’s nervous system. Main sources: same as EPA – oily fish species and some seaweed-based supplements.

While ALA is a beneficial fatty acid, most studies have linked EPA and DHA to favorable effects, especially in the context of cardiovascular disease, brain development, and other conditions. Therefore, it is recommended to consume a variety of omega-3 sources to obtain all three types of these fatty acids.

Synovial fluid and omega-3 connection

Synovial fluid plays a key role in human joints. This viscous fluid acts as a lubricant and shock absorber, protecting cartilage and bones from friction and impact. Proper nutrition and hydration of the body can influence the formation and quality of synovial fluid.

Omega-3 fatty acids, especially EPA and DHA, are known for their anti-inflammatory properties. Studies show that regular consumption of omega-3 rich foods can help reduce inflammation in the joints and improve synovial fluid health.

So, in addition to other benefits for your heart, brain, and overall health, eating foods high in omega-3 can also benefit your joints.

Also, actively hydrating your body with water, especially during intense physical activity, supports optimal joint function and helps maintain proper synovial fluid consistency.

What are product labels and how can you tell the difference between healthy and unhealthy products?

Ingredient List: By law, ingredients are listed in descending order of quantity. Products where whole or minimally processed ingredients come first (e.g., “whole wheat”) are usually better than those where sugar or saturated fats come first.

Nutrient content: Look at the content of fat, saturated fat, salt, sugar, and other ingredients. Foods that are low in sugar, salt and saturated fat and high in protein, vitamins and minerals are generally considered healthy.

Certifications: Some products may carry environmental or organic certifications such as USDA Organic or EU Organic. Such labels indicate that the product was produced without the use of certain pesticides, herbicides, and GMOs.

Fisheries Sustainability: If you’re buying fish products, look for tags that certify fisheries sustainability, such as those from the Marine Stewardship Council (MSC).

“No added sugar” or “non-GMO”: Many products may have these tags. However, “no added sugar” does not always mean that a product is low in calories or has no sugar at all – it may contain other sweeteners.

Shelf life: Fresh foods usually have a short shelf life. Products with a long shelf life may contain preservatives or other additives.

Place of origin: Depending on your region and preferences, place of origin can be an important factor. For example, many people prefer local products because of a smaller ecological footprint and support for local producers.

3. Rationale and examples of research about the imbalance of omega-3 and 6.

The balance between omega-3 and omega-6 is fundamental to human health. Numerous studies over decades have analyzed the effects of each of these fatty acids, as well as the consequences of their imbalance.

Inflammation: A study published in the Journal of Clinical Biochemistry in 2002 indicates that arachidonic acid derivatives (omega-6) may stimulate inflammation. While some omega-3 derivatives such as EPA have anti-inflammatory effects.
[Reference: Ferrucci L., Cherubini A., Bandinelli S., et al. (2006). Relationship of plasma polyunsaturated fatty acids to circulating inflammatory markers. Journal of Clinical Endocrinology & Metabolism, 91(2), 439-446].

Cardiovascular disease: A 2016 review published in Nutrients analyzed data on the association of omega-6 and cardiovascular disease risk. It found that excess omega-6 may increase risk.
[Reference: Patterson E., Wall R., Fitzgerald G. F., Ross R. P., Stanton C. (2012). Health implications of high dietary omega-6 polyunsaturated Fatty acids. Journal of Nutrition and Metabolism, 2012, 539426].

Brain function and depression: According to a 2004 study published in the journal Lipids in Health and Disease, DHA (omega-3) plays a key role in brain development and function. Omega-3 deficiency is associated with an increased risk of developing depression.
[Reference: Conklin S. M., Manuck S. B., Yao J. K., et al. (2007). High ω-6 and low ω-3 fatty acids are associated with depressive symptoms and neuroticism. Psychosomatic Medicine, 69(9), 932-934].

Joint Inflammation: A review in Arthritis Research & Therapy in 2016 confirms that omega-3 may help reduce symptoms of inflammatory joint disease.
[Reference: Proudman S. M., James M. J., Spargo L. D., et al. (2008). Fish oil in recent onset rheumatoid arthritis: a randomized, double-blind controlled trial within algorithm-based drug use. Annals of the Rheumatic Diseases, 73(11), 1944-1956].

It is important to note that despite extensive research in this area, results may vary. Therefore, it is always advisable to consult a specialist for individualized nutritional advice.

%d bloggers like this: